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After hitting rock-bottom from his own addictions during the birth of his twins, William Banks strikes a tentative deal with God. In exchange for a second chance, he vows to kick his addictions and dedicate his life to helping others. Now, along with his unconventional team, he helps people get clean from their own addictions of sex, drugs, alcohol and gambling by any means necessary.

U.S. Marshal Mary Shannon must hunt down witnesses for federal cases in the witness protection program while also managing a rather dysfunctional family and her own personal life.

Dr. Jacob Hood is a brilliant biophysicist and special science advisor to the government who investigates scientific crises and oddities. His crusade is to protect the substance of science against those who would abuse and misuse scientific discoveries for their own gain.

Grace Hanadarko is a tormented, fast-living Oklahoma City police detective who, despite having an excellent career in solving crimes, takes self-destruction to new heights. After seeing tremendous tragedy, both professionally and personally, Grace reaches a turning point one night and meets a rough-hewn angel with a similar past who wants to help lead her back to the right path.

Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.

Adrian Monk was once a rising star with the San Francisco Police Department, legendary for using unconventional means to solve the department's most baffling cases. But after the tragic (and still unsolved) murder of his wife Trudy, he developed an extreme case of obsessive-compulsive disorder. Now working as a private consultant, Monk continues to investigate cases in the most unconventional ways.

CSI: Miami follows Crime Scene Investigators working for the Miami-Dade Police Department as they use physical evidence, similar to their Las Vegas counterparts, to solve grisly murders. The series mixes deduction, gritty subject matter, and character-driven drama in the same vein as the original series in the CSI franchise, except that the Miami CSIs are cops first, scientists second.

After her dentist husband of 20 years leaves her for his dental hygienist, Reba Hart's seemingly perfect world is turned upside down.

A Las Vegas team of forensic investigators are trained to solve criminal cases by scouring the crime scene, collecting irrefutable evidence and finding the missing pieces that solve the mystery.

Level 9 is an American television program broadcast on UPN, first aired in 2000. The plot revolved around a secret agency within the government, staffed by government agents, tech-savvy geeks, and former criminal hackers, which is tasked with solving or preventing cyber crimes. Thirteen episodes were produced, ten of which were aired on UPN, before the program was canceled in January 2001 due to low ratings. In August 2006, the Sci-Fi Channel acquired rerun rights to the series which was added to their schedule in June 2007. Sci-Fi aired the episodes never shown by UPN in February 2008.
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