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Travis Marks and Wes Mitchell are two partners who – apart from their polarity and odd couple behavior – have a seven-year track record as the Los Angeles Police Department's best detectives in the Robbery-Homicide Division. Since their constant bickering is interfering with work, their new-age captain – who found counseling changed his life – sends them to couples' therapy.

Dr. Daniel Pierce, a neuroscientist and professor, is recruited to help the federal government crack difficult cases. His intimate knowledge of human behavior and masterful understanding of the mind give him an extraordinary ability to read people, but his eccentric view of the world and less-than-stellar social skills can often interfere with his work.

Chicagoan Frank Gallagher is the proud single dad of six smart, industrious, independent kids, who without him would be... perhaps better off. When Frank's not at the bar spending what little money they have, he's passed out on the floor. But the kids have found ways to grow up in spite of him. They may not be like any family you know, but they make no apologies for being exactly who they are.

A raw and authentic look into the Los Angeles crime scene, going far inside the lives of cops, criminals, victims and their families. The show centers on four main characters: Officer John Cooper, a seasoned cop who will have to prove himself again after recovering from surgery; Officer Ben Sherman, who still has much to learn after recently completing his training rotation; Detective Lydia Adams, whose unending caseload hits closer to home; and Sammy Bryant, a former detective who decided to go back to being a uniform cop after the traumatic death of his partner.

Many lawyers consider themselves prophets, but Eli Stone may be the real deal. Eli has built a successful career at a top law firm in San Francisco representing only the biggest and richest corporations that make a habit of screwing over the little guy. But after experiencing a series of odd hallucinations, Eli seeks to find a deeper meaning to life while trying not to lose his job and destroy his relationship with the bosses' daughter. When Eli discovers an aneurysm in his brain, he wonders if his condition is truly medical or if perhaps he now has a higher calling.

Grace Hanadarko is a tormented, fast-living Oklahoma City police detective who, despite having an excellent career in solving crimes, takes self-destruction to new heights. After seeing tremendous tragedy, both professionally and personally, Grace reaches a turning point one night and meets a rough-hewn angel with a similar past who wants to help lead her back to the right path.

An elite team of FBI profilers analyze the country's most twisted criminal minds, anticipating their next moves before they strike again. The Behavioral Analysis Unit's most experienced agent is David Rossi, a founding member of the BAU who returns to help the team solve new cases.

Deputy Police Chief Brenda Leigh Johnson transfers from Atlanta to LA to head up a special unit of the LAPD that handles sensitive, high-profile murder cases. Johnson's quirky personality and hard-nosed approach often rubs her colleagues the wrong way, but her reputation as one of the world's best interrogator eventually wins over even her toughest critics.

Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.

The Philadelphia homicide squad's lone female detective finds her calling when she is assigned cases that have never been solved. Detective Lilly Rush combines her natural instincts with the updated technology available today to bring about justice for all the victims she can.
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