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After 20 years, Ana María returns to Mexico and vies for control of her family's tequila empire as it threatens to crumble under corruption and secrets.

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La Patrona is a Spanish-language telenovela produced by United States-based television network Telemundo Studios, Miami and Mexican Argos Comunicación. The telenovela is a remake of the Venezuelan telenovela La Dueña, written by José Ignacio Cabrujas. The name reflects a local term or slang in Mexico to address a person recognized as the main boss. However, the title is also a reflection of both the protagonist and the antagonist struggle to conquer power, authority and respect in a labor field traditionally deemed to be a man's job.

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Paulino Córdoba, Gabino Roura, Rodolfo Huerta, and Matías Quiroga have been friends since childhood; however, as adults, their priorities shifted, and a sin now threatens to destroy their friendship. Paulino owns the El Milagro apple hacienda and is married to Rosario; they have two children, César and Lucrecia. Rosario has always favored her son while openly rejecting her daughter. Lucrecia was raised by Delfina, Rosario’s maid and Manuel’s mother.
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