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The inhabitants of a small, remote island have been practicing voodoo rites and worshipping an evil priest named Damballah for years, but the local law officials generally turn a blind eye to this death cult's bizarre activities. Captain Labesch arrives from the mainland, determined to crack down on the island's lawlessness and clean up the ineffectual, hard-drinking police force. He appeals for assistance from wealthy plantation tycoon Carl Van Molder, who owns nearly half of the island and wields a great deal of influence over the population. Van Molder has made the study of parapsychology his life's work and believes in the secret powers of the mind. He warns Labesch not to interfere with this forgotten island's ancient ways. Also visiting is Van Molder's niece, Annabella, a temperance crusader who wants her uncle to help fund the International Anti-Saloon League. She falls in love with handsome police lieutenant Andrew Wilhelm

When an archaeologist uncovers a strange skull in a foreign land, the residents of a nearby town begin to disappear, leading to further inexplicable occurrences.

Harry and Valerie Spalding arrive in the remote Cornish village to an unwelcoming and suspicious population. Harry's brother dies suddenly, bitten by a lethal reptilian bite. They befriend a young woman Anna whose tyrannical father controls her life and, as they discover that others in the village have suffered a similar fate, their investigations lead to Anna. What they uncover is a victim of the most terrifying legacy... a destiny of mutilation and murder.