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Broncho Billy is requested to resign his office as sheriff. John Jenkin's son is appointed his successor. The new sheriff is given a severe fright a few days later when the bad man of the town enters his office and threatens to shoot him. After this episode he sends in his resignation not having the nerve to serve as sheriff.

A rogue scientist near a small desert town arouses the suspicion of the town's doctor when his lab assistant is found dead from a case of acromegaly, which took only four days to develop. As the doctor investigates, aided by the scientist's new female assistant, they discover that something is devouring local cattle and humans in increasingly large quantities.