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Arthur Conan Doyle reveals the story behind Sherlock Holmes and his mysteries by telling about Dr. Joseph Bell, from whom he drew his inspiration, after meeting him as a medical student in Edinburgh. This TV movie served as the pilot for the later released minisseries Murder Rooms: Mysteries of the Real Sherlock Holmes produced by the BBC. The series then picks up with Sir Arthur Conan Doyle's time as a general practitioner in Southsea, solving mysteries with the help of his mentor, Dr Joseph Bell, who is still based in Edinburgh.

Erika Toda joins a law firm headed by Serizawa-san, on the first case she meets Enomoto Kei of Tokyo total security who unlocks Serizawa who has accidentally been trapped in a vault. Form thereon the trio solve 10 cases related to the locked room. Enomoto always makes a small scale model and thinks technically in terms of security and locks to solve cases, while Serizawa assists by hinting some circumstantial evidences. Serizawa is always ready to take credit of new found fame.

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A hotelier killed a customer. The play in the hotel's closed room began with sudden violence. As if to ridicule the irresistible woman, a video camera or a horrendous torture device set up by the customer was being used. And then.., When the physical humiliation tore into the woman's heart, she turned into a weapon.

A murder occurs in a black-and- white portrait studio, but who is the murderer?