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This engaging made-for-television movie follows the adventures of Ginny "Sweetie Pie" LaRosa (Kim Darby), who needs money after her trucker husband, Jack (Fred Willard), is shot by hijackers. Fortunately, she finds a partner in Flatbed Annie (Annie Potts), a freewheelin' driver. The women form an unlikely but profitable friendship while fending off the repo man who wants the truck and the criminals who are after the cocaine hidden in it.

A rogue scientist near a small desert town arouses the suspicion of the town's doctor when his lab assistant is found dead from a case of acromegaly, which took only four days to develop. As the doctor investigates, aided by the scientist's new female assistant, they discover that something is devouring local cattle and humans in increasingly large quantities.