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When the Littles adopt Stuart, the mouse, George is initially unwelcoming to his new brother, and the family cat, Snowbell, is even less enthusiastic. Stuart resolves to face these difficulties with as much pluck and courage as he can muster.

In the 1800s, a stormy love relationship develops quickly between a young medical student and a woman believing herself to be the daughter of his scientist uncle, the student having never heard of her before their chance encounter and both unaware that she is the result of the scientist's illegal experiments with artificial insemination..

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Being different often means feeling alone. But it means being unique, unconventional and rare too. What happens then when two lonely and unusual people meet? Problems become shared and lives connected.