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Natalie, a gifted New York photographer, has a troubled past reflected in her art. When she struggles to make ends meet in the city, her agent, arranges an assignment in Boston for a considerable sum of money. Unable to turn it down in her dire straits, Natalie takes the job -- only to find that her estranged gay brother, Roy, is the employer. Roy wants to mend their broken past, but must convince her to stay long enough to do so.

While caring for her brother along with her audacious mother, a teenager strikes up an unlikely friendship with an eccentric activist who is protesting one of the most landmark medical cases of all time.