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A group of people fight for their small town after vampires take over the world.

Nora Barkin is an aspiring actress who supports herself by working for a courier service. No sooner has Nora's friend and coworker Bill Reagan jubilantly announced that he possesses a lottery ticket worth 13 million dollars than Bill is killed by an unknown assailant. Though discouraged from doing so by investigating detective Marinello, Nora insists upon trying to solve Bill's murder herself.

A trio of interweaved transgressive tales, telling a bizarre stories of suburban patricide and a miraculous flight from justice, a mad sex experiment which unleashes a disfiguring plague, and the obsessive sexual relationship between two prison inmates.

A group of friends decide to renovate an old house located in the middle of nowhere, in the hope of turning it into their crash pad, but shortly after arriving, a strange and seemingly senile old woman is found to be lurking around the premises.
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