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America in the mid-1980s. In the midst of the AIDS crisis and a conservative Reagan administration, six New Yorkers with interconnect lives grapple with life and death, love and sex, heaven and hell.

In the second part, Perestroika, Prior, Joe, Louis, Harper, and Roy continue to navigate love, loss, and loneliness in their attempts to pick up the pieces and find comfort in a chaotic world. Their stories quickly intertwine, as unlikely relationships emerge and develop.
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