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Airline security specialist John Cutter, finally returning to the job after his wife's death, finds himself stuck on a flight being hijacked by notorious terrorist Charles Rane. Unfortunately for the terrorists, they're also stuck with him.

Two uneasy friends, a police officer and a TV talk show host, each pursue the mysterious "handcuff killer" with the aid of an artist who sees - and draws - the killer's crimes before they're committed.

Fearful that their star witness might be murdered, two attorneys hire a protector to bring him from Los Angeles to New York. Jesse Crowder (Fred Williamson) is a no-nonsense tough guy. He buddies up with the witness, an accountant, and they hit the road. Outwitting their foes means taking all manner of conveyance, including automobile, train, and airplane.
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