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Tom, greeting-card writer and hopeless romantic, is caught completely off-guard when his girlfriend, Summer, suddenly dumps him. He reflects on their 500 days together to try to figure out where their love affair went sour, and in doing so, Tom rediscovers his true passions in life.

The basic premise is that Whitney is a really great guy who is considered too gentle, too friendly, and too genuine to be straight. Actually, he's straight, and he's madly in love with his girlfriend Taylor. Whitney has a best friend, Aldo, who is the worst best friend a nice guy ever had. Whitney is ready to marry Taylor, but Taylor keeps telling him to wait. To wait. To wait. Taylor has a secret and Aldo knows the secret. He won't tell, if . . .

Cheryl and Alex Wheeler are seemingly happily married, with two beautiful daughters. But when Alex decides to look up his college sweetheart Suzanne Kennerly, he has no idea that his actions will lead to Cheryl also being reunited with her college sweetheart, Phil Welch.

After struggling and finally conceiving a child, Roxy and Vinnie Ventola, a successful television writing couple, learns that their newborn has AIDS. Soon afterward, the two parents are also diagnosed with the fatal virus.

A husband tries to keep his comatose wife alive by allowing doctors to terminate her pregnancy. Hearing about this, anti-abortion protesters start a legal campaign to gain legal custody of the fetus.

Janet recalls the summer during her teenage years when her family moved yet again for her father's job with NASA, including him teaching her to drive and her meeting her first boyfriend.

The girlfriends of softball players decide to form their own team as a way of avenging their neglect.
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