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Drama critic Larry Mackay, his wife Kate and their four sons move from their crowded Manhattan apartment to an old house in the country. While housewife Kate settles into suburban life, Larry continues to enjoy the theater and party scene of New York.

A disillusioned writer explores the subterranean depths of San Francisco's North Beach district.

Episcopalian minister Gil Allen keeps up his college days interest in boxing by working out at a gym run by his friend, Tom Kelley but declines offers to fight in an actual staged bout, until he realizes he could use the prize money to purchase equipment for local polio victims. Keeping his real identity secret and hoping to step away after one big payday, Gil signs a contract to fight for greedy promoter Gus MacAuliffe.

Former radio singer Kay learns from her gossipy friends that her husband, Steve, has had an affair with chorus girl Crystal. Devastated, Kay tries to ignore the information, but when Crystal performs one of her musical numbers at a charity benefit, she breaks down and goes to Reno to file for divorce. However, when she hears that gold-digging Crystal is making Steve unhappy, Kay resolves to get her husband back. The Opposite Sex is a remake of the 1939 comedy The Women.

Jenny Stewart is a tough Broadway musical star who doesn't take criticism from anyone. Yet there is one individual, Tye Graham, a blind pianist who may be able to break through her tough exterior.

Pat Pemberton is a brilliant athlete, except when her domineering fiancé is around. The ladies golf championship is in her reach until she gets flustered by his presence at the final holes. He wants them to get married and forget the whole thing, but she cannot give up on herself that easily. She enlists the help of Mike Conovan, a slightly shady sports promoter. Together they face mobsters, a jealous boxer, and a growing mutual attraction.

A scrupulously honest lawyer discovers that the client he's gotten off was really guilty.

When a group of astronomers calculate a star is on a course to slam into Earth, a few days before, it's accompanying planet will first pass close enough to the Earth to cause havoc on land and sea. They set about building a rocket so a few selected individuals can escape to the planet.

A detective tries to prevent the assassination of President-elect Abraham Lincoln during a train ride headed for Washington in 1861.

The wedding of Ellen and David is halted by a stranger who insists that the bride is already married to someone else. Though the flabbergasted Ellen denies the charge, the interloper produces enough evidence that his accusation must be investigated. Ellen and David travel to the small coastal town where her first wedding allegedly occurred. There, they meet a number of individuals whose stories make Ellen question her own sanity.
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