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On their cross-country drive, a married couple, Jeff and Amy Taylor, experience car trouble after their SUV breaks down. Stranded in the New Mexico desert, the two catch a break when a passing truck driver offers Amy a ride to a nearby café to call for help. Meanwhile, Jeff is able to fix the car and make his way to the café, but Amy isn't there. He tracks down the trucker ― who tells the police he's never seen Jeff or his wife before. Jeff then begins a desperate, frenzied search for Amy.

After her daughter is kidnapped, a mother discovers that there can be something even worse after "the worst."

Bryan Mills, a former government operative, is trying to reconnect with his teenage daughter Kim. After reluctantly agreeing with his ex-wife to let Kim go to Paris on vacation with a friend, his worst nightmare comes true. While on the phone with his daughter shortly after she arrives in Paris, she and her friend are abducted by a gang of human traffickers. Working against the clock, Bryan relies on his extensive training and skills to track down the ruthless gang that abducted her and launch a one-man war to rescue his daughter.

A young Australian woman reluctantly agrees to help a Chinese mother search for her missing daughter and becomes involved in human trafficking and the sex slave trade.

A high school coach, whose teenage daughter was murdered, takes matters into his own hands by going after the men who kidnap his students for their sex trafficking operation.