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Sherlock Holmes investigates a series of so-called "pajama suicides". He knows the female villain behind them is as cunning as Moriarty and as venomous as a spider. Based on "The Sign of Four" and the short stories "The Dying Detective", "The Final Problem", "The Speckled Band" and "The Adventure of the Devil's Foot".

Holmes and Dr. Watson take on the case of a beautiful woman whose husband has vanished. The investigation proves strange indeed, involving six missing midgets, villainous monks, a Scottish castle, the Loch Ness monster, and covert naval experiments.

The millionaire's child is kidnapped. Sherlock Holmes after many thrilling adventures and narrow escapes rescues the child.

Sherlock Holmes is forced to confront his age and health condition as he struggles to solve the murder of a fellow detective.

Two dubious characters disguise themselves as Holmes and Watson to gain attention and end up chasing counterfeiters and stolen stamps.
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